R University of Roehampton London

Courses
Courses
Student Life
Student Life

At Roehampton, we provide a wide range of opportunities for you to get involved, through volunteering, playing sport or music, or joining one of our many active student societies. We also have a beautiful parkland campus, in the heart of south-west London.
Student Support
Student Support

As a student, you will have be supported not just by those that teach you, but also by the wide range of staff who will be with you throughout your studies.

We provide health and wellbeing services, financial guidance and support to develop your study skills. You will also have access to careers advice, work placements, paid and voluntary work opportunities and career mentoring.
Research
Research

At Roehampton, we are focused on creating new knowledge and ideas that help us to understand our world and make it a better place. We are ranked the most research-intensive modern university in the UK. Our staff undertake world-class research across all our academic departments. This means that if you join us as a student, you will benefit from being taught by leading thinkers from your first year of study.
- Research and Knowledge Exchange Centres
  
  Arts and Creative Exchange
  
  Equality, Justice and Social Change
  
  Inclusive Humanities
  
  Integrated Research in Life and Health Sciences
  
  Learning, Teaching and Human Development
  
  Psychological Wellbeing
  
  Sustainability and Responsible Management
Contact us

Development of novel anti-cancer phosphatase activator

Staff involved: Dr Maria Teresa Esposito, Dr Michelle Sahai

Protein phosphorylation is a post-translational modification, regulated by phosphatase and kinases, that governs the activity of signalling pathways in cells. This process is often aberrant in cancer. Kinases have been studied as potential therapeutic targets for decades, and several kinases inhibitors have been approved for treatment of cancer. Phosphatase have been considered undruggable but with the development of novels tools to study protein-protein interaction, the time is ready to uncover the therapeutic potential of phosphatase regulators. In collaboration with Cyclica we are investigating novel small molecules for therapy of leukemia using computational approaches and machine learning on an AI-augmented platform.

Leukemic cells undergoing differentiation

This work is featured on the Leukaemia UK website here: https://www.leukaemiauk.org.uk/mll-identifying-how-mixed-lineage-leukaemia-resists-chemotherapy-treatment